Proteomics

Dataset Information

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Phosphoproteomic analysis of ADNP-mutant mice


ABSTRACT: We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory along with social and anxiety-related deficits in adults, long after the juvenile-stage decrease of ADNP protein levels to ~10% of the newborn level. Adnp-mutant mice show abnormally enhanced long-term potentiation in adults but not in juveniles. This is accompanied by CaMKIIa hyperactivity involving increased baseline autophosphorylation and altered phosphorylation of CaMKIIa substrates, as revealed by unbiased proteomic analyses.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yeji Yang  

LAB HEAD: Eunjoon Kim

PROVIDER: PXD037325 | Pride | 2023-07-11

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20200617_Swissprot_Mouse_ISO4prot.fasta Fasta
210111_32482_KA_L.raw Raw
210111_32483_KA_L.raw Raw
210111_32484_KA_L.raw Raw
210111_32485_KA_L.raw Raw
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