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CSF and Brain neuropeptidomics in dementia pathophysiology

ABSTRACT: Development of a mass spectrometry biomarker assay to characterize cerebrospinal fluid and brain proteoforms of the granin family of neuropeptides in dementia pathophysiology

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Cerebrospinal Fluid

SUBMITTER: Michael Bremang

LAB HEAD: Dr Becky Carlyle

PROVIDER: PXD037367 | Pride | 2023-07-21

REPOSITORIES: Pride

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			Action	DRS
	19080-001.msf	Msf
	19080-001.raw	Raw
	19080-002.msf	Msf
	19080-002.raw	Raw
	19080-003.msf	Msf

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Publications

Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease.

Quinn James P JP Ethier Elizabeth C EC Novielli Angelo A Malone Aygul A Ramirez Christopher E CE Salloum Lauren L Trombetta Bianca A BA Kivisäkk Pia P Bremang Michael M Selzer Stefan S Fournier Marjorie M Das Sudeshna S Xing Yaoyi Y Arnold Steven E SE Carlyle Becky C BC

Journal of the American Society for Mass Spectrometry 20230313 4

The granin neuropeptide family is composed of acidic secretory signaling molecules that act throughout the nervous system to help modulate synaptic signaling and neural activity. Granin neuropeptides have been shown to be dysregulated in different forms of dementia, including Alzheimer's disease (AD). Recent studies have suggested that the granin neuropeptides and their protease-cleaved bioactive peptides (proteoforms) may act as both powerful drivers of gene expression and as a biomarker of syn ...[more]

PMID: 36912488

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