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DIA MS analysis of primary breast cancers with no recurrence

ABSTRACT: We employed our recently developed proteogenomic workflow (De Marchi et al, 2021) to analyze a cohort of 21 primary breast cancers by RNA sequencing and mass spectrometry.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: Tommaso De Marchi

LAB HEAD: Emma Niméus

PROVIDER: PXD037428 | Pride | 2023-02-03

REPOSITORIES: Pride

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Proteogenomics decodes the evolution of human ipsilateral breast cancer.

De Marchi Tommaso T Pyl Paul Theodor PT Sjöström Martin M Reinsbach Susanne Erika SE DiLorenzo Sebastian S Nystedt Björn B Tran Lena L Pekar Gyula G Wärnberg Fredrik F Fredriksson Irma I Malmström Per P Fernö Mårten M Malmström Lars L Malmstöm Johan J Niméus Emma E

Communications biology 20230202 1

Ipsilateral breast tumor recurrence (IBTR) is a clinically important event, where an isolated in-breast recurrence is a potentially curable event but associated with an increased risk of distant metastasis and breast cancer death. It remains unclear if IBTRs are associated with molecular changes that can be explored as a resource for precision medicine strategies. Here, we employed proteogenomics to analyze a cohort of 27 primary breast cancers and their matched IBTRs to define proteogenomic det ...[more]

PMID: 36732562

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