Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Embryonic Stem Cell
SUBMITTER: Yutong Chen
LAB HEAD: Yi Lin
PROVIDER: PXD037432 | Pride | 2023-01-10
REPOSITORIES: Pride
Sun Hongyao H Chen Yutong Y Yan Kun K Shao Yanqiu Y Zhang Qiangfeng C QC Lin Yi Y Xi Qiaoran Q
The EMBO journal 20221216 3
TRIM33 is a chromatin reader required for mammalian mesendoderm differentiation after activation of Nodal signaling, while its role in mESCs is still elusive. Here, we report that TRIM33 co-localizes with promyelocytic leukemia nuclear bodies (PML-NBs) specifically in mESCs, to mediate Nodal signaling-directed transcription of Lefty1/2. We show that TRIM33 puncta formation in mESCs depends on PML and on specific assembly of PML-NBs. Moreover, TRIM33 and PML co-regulate Lefty1/2 expression in mES ...[more]