Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Fenglong Jiao
LAB HEAD: Lan Huang
PROVIDER: PXD037443 | Pride | 2023-07-20
REPOSITORIES: Pride
Jiao Fenglong F Salituro Leah J LJ Yu Clinton C Gutierrez Craig B CB Rychnovsky Scott D SD Huang Lan L
Analytical chemistry 20230118 4
The development of MS-cleavable cross-linking mass spectrometry (XL-MS) has enabled the effective capture and identification of endogenous protein-protein interactions (PPIs) and their residue contacts at the global scale without cell engineering. So far, only lysine-reactive cross-linkers have been successfully applied for proteome-wide PPI profiling. However, lysine cross-linkers alone cannot uncover the complete PPI map in cells. Previously, we have developed a maleimide-based cysteine-reacti ...[more]