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Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy

ABSTRACT: The anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We performed proteomics on whole heart tissue of MPO-deficient mice on C57BL/6J background and wildtype (WT) littermates seven days after intravenous injection of the anthracycline Doxorubicin (20 mg/kg bodyweight, dissolved in saline) or saline (NaCl).

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Prerana Wagle

LAB HEAD: Martin Mollenhauer

PROVIDER: PXD037524 | Pride | 2023-08-30

REPOSITORIES: Pride

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