Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Differentiation In Spinal Cord
DISEASE(S): Amyotrophic Lateral Sclerosis
SUBMITTER: 
Yingzhen Zhang
LAB HEAD: Guo Yansu
PROVIDER: PXD037555 | Pride | 2023-03-11
REPOSITORIES: Pride
Publications
Endothelin-1, over-expressed in SOD1<sup>G93A</sup> mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis.
Zhang Yingzhen Y Chen Lin L Li Zhongzhong Z Li Dongxiao D Wu Yue Y Guo Yansu Y
Frontiers in cellular neuroscience 20221201
Endothelin-1 (ET-1), a secreted signaling peptide, is suggested to be involved in multiple actions in various tissues including the brain, but its role in amyotrophic lateral sclerosis (ALS) remains unknown. In this study, we detected the expression changes as well as the cellular localization of ET-1, endothelin A (ET-A) and endothelin B (ET-B) receptors in spinal cord of transgenic SOD1-G93A (TgSOD1-G93A) mice, which showed that the two ET receptors (ET-Rs) expressed mainly on neurons and decr ...[more]
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