G3BP1-dependent suppression of polyglutamine aggregation in Huntington’s models and its failure upon stress granule formation

ABSTRACT: To define the interactome of huntingtin protein (HTT) in human neurons, we assessed interactors of HTT with coimmunoprecipitation experiments with huntingtin antibody or polyqlutamine antibody (it only recognizes mutant huntingtin protein with abnormal polyqlutamine expansion) in striatal neurons differentiated from control and patient-derived iPSC lines (HD-iPSCs). GFP antibody used as a negative control.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Huntington Disease

SUBMITTER: Proteomics Facility  

LAB HEAD: David Vilchez

PROVIDER: PXD037618 | Pride | 2022-12-02

REPOSITORIES: Pride