Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Benjamin Lau
LAB HEAD: Prof. Dr. Ed Hurt
PROVIDER: PXD037619 | Pride | 2023-03-11
REPOSITORIES: Pride
Lau Benjamin B Beine-Golovchuk Olga O Kornprobst Markus M Cheng Jingdong J Kressler Dieter D Jády Beáta B Kiss Tamás T Beckmann Roland R Hurt Ed E
Cell reports 20221101 8
Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction, but little is known about how the many different snoRNAs that modify the pre-rRNA are timely guided to their target sites. Here, we report a role for Cms1 in such a process. Initially, we discovered CMS1 as a null suppressor of a nop14 mutant impaired in Rrp12-Enp1 factor recruitment to the 90S. Further investigations detected Cms1 at the 18S rRNA 3' major domain of an early 90S that carried H/ACA snR83, which is know ...[more]