Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Laura Liesinger
LAB HEAD: Ruth Birner-Gruenberger
PROVIDER: PXD037649 | Pride | 2023-05-10
REPOSITORIES: Pride
Schrom Silke S Kleinegger Florian F Anders Ines I Hebesberger Thomas T Karner Christina C Liesinger Laura L Birner-Gruenberger Ruth R Renner Wilfried W Pichler Martin M Grillari Regina R Aigelsreiter Ariane A Rinner Beate B
Cancers 20230314 6
Cholangiocarcinoma (CCA) are characterized by their desmoplastic and hypervascularized tumor microenvironment (TME), which is mainly composed of tumor cells and cancer-associated fibroblasts (CAFs). CAFs play a pivotal role in general and CCA tumor progression, angiogenesis, metastasis, and the development of treatment resistance. To our knowledge, no continuous human in vivo-like co-culture model is available for research. Therefore, we aimed to establish a new model system (called MUG CCArly) ...[more]