Dataset Information
Identification of interaction partners of novel polyacetylene
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte, Whole Body
SUBMITTER: 
Michael Ristow
LAB HEAD: Dr. Michael Ristow
PROVIDER: PXD037671 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging.
Nature communications 20231208 1
To ameliorate or even prevent signatures of aging in ultimately humans, we here report the identification of a previously undescribed polyacetylene contained in the root of carrots (Daucus carota), hereafter named isofalcarintriol, which we reveal as potent promoter of longevity in the nematode C. elegans. We assign the absolute configuration of the compound as (3 S,8 R,9 R,E)-heptadeca-10-en-4,6-diyne-3,8,9-triol, and develop a modular asymmetric synthesis route for all E-isofalcarintriol stere ...[more]
