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DICAR+/- mouse heart Label free LC-MS

ABSTRACT: The level of ubiquitin protein of the heart of DICAR+/- compared with wild type

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Disease Free

SUBMITTER: Qiong Yuan

LAB HEAD: Qiong Yuan

PROVIDER: PXD037732 | Pride | 2023-03-11

REPOSITORIES: Pride

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Publications

CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes.

Yuan Qiong Q Sun Yunwei Y Yang Fan F Yan Dan D Shen Meihua M Jin Zhigang Z Zhan Lin L Liu Guangqi G Yang Ling L Zhou Qianyi Q Yu Zhijun Z Zhou Xiangyu X Yu Yang Y Xu Yong Y Wu Qingming Q Luo Jianfang J Hu Xiamin X Zhang Chunxiang C

Signal transduction and targeted therapy 20230308 1

In this study, we identified that a conserved circular RNA (circRNA) DICAR, which was downregulated in diabetic mouse hearts. DICAR had an inhibitory effect on diabetic cardiomyopathy (DCM), as the spontaneous cardiac dysfunction, cardiac cell hypertrophy, and cardiac fibrosis occurred in DICAR deficiency (DICAR<sup>+/-</sup>) mice, whereas the DCM was alleviated in DICAR-overexpressed DICAR<sup>Tg</sup> mice. At the cellular level, we found that overexpression of DICAR inhibited, but knockdown ...[more]

PMID: 36882410

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