Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Dorsal Root Ganglion
DISEASE(S): Herpes Simplex
SUBMITTER: Keith Ray
LAB HEAD: Andrea S. Bertke
PROVIDER: PXD037767 | Pride | 2023-03-11
REPOSITORIES: Pride
Harrell Telvin L TL Davido David J DJ Bertke Andrea S AS
International journal of molecular sciences 20230202 3
Herpes simplex virus 1 (HSV-1) enters sensory neurons with the potential for productive or latent infection. For either outcome, HSV-1 must curtail the intrinsic immune response, regulate viral gene expression, and remove host proteins that could restrict viral processes. Infected cell protein 0 (ICP0), a virus-encoded E3 ubiquitin ligase, supports these processes by mediating the transfer of ubiquitin to target proteins to change their location, alter their function, or induce their degradation ...[more]