Cry1 and Per2 protein complex in mouse liver
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Li Wang
LAB HEAD: Aziz Sancar
PROVIDER: PXD037841 | Pride | 2023-03-11
REPOSITORIES: Pride
Publications
Analysis of mammalian circadian clock protein complexes over a circadian cycle.
Cao Xuemei X Wang Li L Selby Christopher P CP Lindsey-Boltz Laura A LA Sancar Aziz A
The Journal of biological chemistry 20230120 3
Circadian rhythmicity is maintained by a set of core clock proteins including the transcriptional activators CLOCK and BMAL1, and the repressors PER (PER1, PER2, and PER3), CRY (CRY1 and CRY2), and CK1δ. In mice, peak expression of the repressors in the early morning reduces CLOCK- and BMAL1-mediated transcription/translation of the repressors themselves. By late afternoon the repressors are largely depleted by degradation, and thereby their expression is reactivated in a cycle repeated every 24 ...[more]
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