Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro, LTQ Orbitrap Velos
ORGANISM(S): Pseudomonas Aeruginosa Pa14
SUBMITTER: Lothar Jaensch
LAB HEAD: Lothar Jänsch, Wulf Blankenfeldt
PROVIDER: PXD038000 | Pride | 2023-03-11
REPOSITORIES: Pride
Borgert Sebastian Roman SR Henke Steffi S Witzgall Florian F Schmelz Stefan S Zur Lage Susanne S Hotop Sven-Kevin SK Stephen Steffi S Lübken Dennis D Krüger Jonas J Gomez Nicolas Oswaldo NO van Ham Marco M Jänsch Lothar L Kalesse Markus M Pich Andreas A Brönstrup Mark M Häussler Susanne S Blankenfeldt Wulf W
Nature communications 20221201 1
Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three intertwined quorum sensing systems control virulence of P. aeruginosa, with the rhl circuit playing the leading role in late and chronic infections. The majority of traits controlled by rhl transcription factor RhlR depend on PqsE, a dispensable thioesterase in Pseudomonas Quinolone Signal (PQS) biosynthesis that interferes wit ...[more]