Multi-omics profiling of lung samples from genetically diabetic pigs reveals reduced ALOX15 expression and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu

ABSTRACT: To evaluate molecular consequences of insulin-deficient diabetes mellitus for lung tissue, we used clinically diabetic pig model of mutant INS gene induced diabetes of youth (MIDY). A multi-omics analysis combining in-depth data-independent acquisition proteomics, and targeted lipidomics revealed multiple dysregulated proteins and lipids and associated biological pathways in the MIDY lung.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Lung

DISEASE(S): Diabetes Mellitus

SUBMITTER: Bachuki Shashikadze  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD038014 | Pride | 2024-07-01

REPOSITORIES: Pride