Dataset Information
Stable Isotope Labeling using Amino acids in Cell culture (SILAC) (local data base)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colon
SUBMITTER: 
Sonia Domínguez
LAB HEAD: José Manuel Cuezva
PROVIDER: PXD038109 | Pride | 2023-10-24
REPOSITORIES: Pride
Publications
IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.
Cell death & disease 20230712 7
ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly variable. In intestinal cells, the overexpression of IF1 protects against colon inflammation. Herein, we have developed a conditional IF1-knockout mouse model in intestinal epithelium to investigate the role of IF1 in mitochondrial function and tissue homeostasis. The results show that IF1-ablated mice have increased ATP synthase/hydrolase ...[more]