LC-MS/MS-based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1

ABSTRACT: The study is based on the identification of serum protein biomarkers for NT 1. A total of 27 serum samples were collected (16 NT 1 and 11 controls), the altered expression levels of low-abundant proteins (DEPs) associated with narcolepsy type 1 was investigated by comparing the proteomes of the two sample cohorts. DEPs that are revealed to be most related to NT 1 pathogenesis and have high levels of fold changes were further targeted and validated by LC-PRM-MS. Then, the effects of the DEPs were explored by system biology analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Narcolepsy

SUBMITTER: Akeem Sanni  

LAB HEAD: Yehia Mechref

PROVIDER: PXD038248 | Pride | 2023-05-10

REPOSITORIES: Pride