Dia-PASEF analysis of human amygdala in Alzheimer’s disease
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: 
Daniel Saiz-Sanchez
LAB HEAD: Alino Martinez-Marcos
PROVIDER: PXD038322 | Pride | 2023-06-28
REPOSITORIES: Pride
Publications
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia-PASEF analysis.
Gonzalez-Rodriguez Melania M Villar-Conde Sandra S Astillero-Lopez Veronica V Villanueva-Anguita Patricia P Ubeda-Banon Isabel I Flores-Cuadrado Alicia A Martinez-Marcos Alino A Saiz-Sanchez Daniel D
Brain pathology (Zurich, Switzerland) 20230618 5
Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid-β (Aβ) and Tau proteins. According to the prion-like hypothesis, both proteins can seed and disseminate through brain regions through neural connections and glial cells. The amygdaloid complex (AC) is involved early in the disease, and its widespread connections with other brain regions indicate that it is a hub for propagating pathology. To characterize changes in the AC as well as the involvement of neuronal ...[more]
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