Proteomics

Dataset Information

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Human osteosarcoma and adjacent normal tissues


ABSTRACT: Osteosarcoma is the most common primary bone cancer in children, adolescents and young adults. It is a rare cancer type. To obtain a comprehensive view of protein expression in osteosarcoma, quantitative TMT–MS was performed with six pairs of osteosarcoma specimens and adjacent normal tissue.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Whole Body

SUBMITTER: Lin Qi  

LAB HEAD: Lin Qi

PROVIDER: PXD038452 | Pride | 2025-05-13

REPOSITORIES: Pride

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Publications

Integrated multiomic analysis and high-throughput screening reveal potential gene targets and synergetic drug combinations for osteosarcoma therapy.

Zhang Wenchao W   Qi Lin L   Liu Zhongyue Z   He Shasha S   Wang Cheng-Zhi CZ   Wu Ying Y   Han Lianbin L   Liu Zhenxin Z   Fu Zheng Z   Tu Chao C   Li Zhihong Z  

MedComm 20230712 4


Although great advances have been made over the past decades, therapeutics for osteosarcoma are quite limited. We performed long-read RNA sequencing and tandem mass tag (TMT)-based quantitative proteome on osteosarcoma and the adjacent normal tissues, next-generation sequencing (NGS) on paired osteosarcoma samples before and after neoadjuvant chemotherapy (NACT), and high-throughput drug combination screen on osteosarcoma cell lines. Single-cell RNA sequencing data were analyzed to reveal the he  ...[more]

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