Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Fibroblast
DISEASE(S): Type 1 Diabetes Mellitus
SUBMITTER: Giorgio Arrigoni
LAB HEAD: Giorgio Arrigoni
PROVIDER: PXD038541 | Pride | 2023-02-13
REPOSITORIES: Pride
Di Camillo Barbara B Puricelli Lucia L Iori Elisabetta E Toffolo Gianna Maria GM Tessari Paolo P Arrigoni Giorgio G
International journal of molecular sciences 20230201 3
Protein turnover rate is finely regulated through intracellular mechanisms and signals that are still incompletely understood but that are essential for the correct function of cellular processes. Indeed, a dysfunctional proteostasis often impacts the cell's ability to remove unfolded, misfolded, degraded, non-functional, or damaged proteins. Thus, altered cellular mechanisms controlling protein turnover impinge on the pathophysiology of many diseases, making the study of protein synthesis and d ...[more]