Recognition of host-protective immune activation by Mycobacterium tuberculosis

ABSTRACT: The cytokine interferon-γ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in interferon-γ-activated macrophages by largely unknown mechanisms. We found that interferon-γ specifically bound to pathogenic mycobacteria and enhanced their growth in culture. Proteomic and electron microscopy analyses revealed that interferon-γ directly triggers proliferative activity and virulence phenotype in pathogenic mycobacteria that allow them to survive and grow inside macrophages. These findings suggest that pathogenic mycobacteria may have evolved eukaryotic-like signal transduction mechanisms to recognize host-protective immune activation.

INSTRUMENT(S):

ORGANISM(S): Mycobacterium Bovis Bcg Str. Pasteur 1173p2 Bacteria

DISEASE(S): Pulmonary Tuberculosis

SUBMITTER: Hsin-Yi Wu  

LAB HEAD: Huynh Tan Hop

PROVIDER: PXD038542 | Pride | 2024-09-05

REPOSITORIES: Pride