Magnetic Transferrin Assay (MTA) as a novel approach for discovering serum exosome derived protein biomarkers in neurological diseases

ABSTRACT: We developed TF-based MNPs (TF-MNPs) to isolate blood-derived exosome in this study and isolated the blood-derived exosomes of patients with neuroinflammatory diseases, such as dementia, Parkinson’s disease and multiple sclerosis via this strategy and then evaluated the proteomic profiling of these exosomes to screen for a potential candidate biomarker. Blood was collected from 10 patients in each of the three disease groups. Over 800 serum exosome proteins were identified by highly sensitive nanoflow liquid chromatography-tandem mass spectrometry (LC−MS/MS).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Multiple Sclerosis,Parkinson's Disease,Dementia

SUBMITTER: Hee-Sung Ahn  

LAB HEAD: Kyunggon Kim

PROVIDER: PXD038555 | Pride | 2023-02-20

REPOSITORIES: Pride