Proteomics

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The HAPSTR2 retrogene buffers stress signaling and resilience in mammals

ABSTRACT: Standard anti-FLAG magnetic beads for co-immunoprecipitations, elution in 2x SDS sample buffer, loaded into a stacking gel and then in-gel digested

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Renu Goel  

LAB HEAD: Marc Mendillo

PROVIDER: PXD038642 | Pride | 2023-03-11

REPOSITORIES: Pride

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The HAPSTR2 retrogene buffers stress signaling and resilience in mammals.

Amici David R DR   Cingoz Harun H   Alasady Milad J MJ   Alhayek Sammy S   Phoumyvong Claire M CM   Sahni Nidhi N   Yi S Stephen SS   Mendillo Marc L ML  

Nature communications 20230111 1

We recently identified HAPSTR1 (C16orf72) as a key component in a novel pathway which regulates the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Here, we identify a functional paralog to HAPSTR1: HAPSTR2. HAPSTR2 formed early in mammalian evolution, via genomic integration of a reverse transcribed HAPSTR1 transcript, and has since been preserved under purifying selection. HAPSTR2, expressed primarily in neural and germline tissues and a  ...[more]

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