Tumor-educated platelet extracellular vesicles: proteomic profiling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Platelet
SUBMITTER: 
Paola Patrignani
LAB HEAD: Paola Patrignani
PROVIDER: PXD038674 | Pride | 2023-03-11
REPOSITORIES: Pride
Publications
Tumor-Educated Platelet Extracellular Vesicles: Proteomic Profiling and Crosstalk with Colorectal Cancer Cells.
Contursi Annalisa A Fullone Rosa R Szklanna-Koszalinska Paulina P Marcone Simone S Lanuti Paola P Taus Francesco F Meneguzzi Alessandra A Turri Giulia G Dovizio Melania M Bruno Annalisa A Pedrazzani Corrado C Tacconelli Stefania S Marchisio Marco M Ballerini Patrizia P Minuz Pietro P Maguire Patricia P Patrignani Paola P
Cancers 20230105 2
<h4>Background</h4>Platelet-cancer cell interactions modulate tumor metastasis and thrombosis in cancer. Platelet-derived extracellular vesicles (EVs) can contribute to these outcomes.<h4>Methods</h4>We characterized the medium-sized EVs (mEVs) released by thrombin-stimulated platelets of colorectal cancer (CRC) patients and healthy subjects (HS) on the capacity to induce epithelial-mesenchymal transition (EMT)-related genes and cyclooxygenase (COX)-2(<i>PTGS2</i>), and thromboxane (TX)B<sub>2</ ...[more]
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