Proteomics

Dataset Information

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The central nervous system’s proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2


ABSTRACT: During severe systemic infections with and without sepsis neurological changes are common and range from sickness behavior to septic associated encephalopathy. Encephalopathy is due to a system-wide inflammatory response leading to an often fatal increase in the permeability of the blood-brain barrier. To elucidate the cytotoxic impact and brain-specific host response during coronavirus disease 2019 (COVID-19), we profiled the olfactory mucosa, olfactory bulb, brainstem and cerebellum from deceased COVID-19 patients who underwent rapid autopsy.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebellum, Medulla Oblongata, Olfactory Bulb

DISEASE(S): Covid-19

SUBMITTER: Michael Mülleder  

LAB HEAD: Helena Radbruch

PROVIDER: PXD038693 | Pride | 2023-11-06

REPOSITORIES: Pride

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