The interacted proteins of ALKBH5 and FTO identified by IP-mass

ABSTRACT: Since m6A demethylases (FTO and ALKBH5) have been reported to be involved in pre-mRNA splicing regulation, we hypothesized that dynamic m6A distribution during mRNA maturation might involve removal of m6A in internal exons by FTO or ALKBH5 accompanied by splicing factors. To explore this we performed pull-down assays coupled with protein mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: xin yang  

LAB HEAD: Richard I. Gregory

PROVIDER: PXD038705 | Pride | 2022-12-09

REPOSITORIES: Pride