Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain, Cell Culture
SUBMITTER: Daniel Gilliam
LAB HEAD: Michael Greenberg
PROVIDER: PXD038718 | Pride | 2023-02-15
REPOSITORIES: Pride
Pollina Elizabeth A EA Gilliam Daniel T DT Landau Andrew T AT Lin Cindy C Pajarillo Naomi N Davis Christopher P CP Harmin David A DA Yap Ee-Lynn EL Vogel Ian R IR Griffith Eric C EC Nagy M Aurel MA Ling Emi E Duffy Erin E EE Sabatini Bernardo L BL Weitz Charles J CJ Greenberg Michael E ME
Nature 20230215 7949
Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic neurons<sup>1-5</sup>. Whether neurons have acquired specialized genome protection mechanisms that enable them to withstand decades of potentially damaging stimuli during periods of heightened activity is unknown. Here we identify an activity-dependent DNA repair mechanism in which a new form of the NuA4-TIP60 chromatin modifier assembles ...[more]