Proteomics

Dataset Information

0

Quantitative LC-MS/MS Proteomics of human liver microsomes (healthy controls and normal-tumour from cancer patients)

ABSTRACT: We report quantification of proteins in human liver microsomal samples from 15 healthy volunteers and 18 patients with cancer in the liver (mainly, colorectal cancer liver metastasis). These data can be used in physiologically based pharmacokinetic models to predict appropriate drug doses in patients with cancer in their liver, especially colorectal cancer liver metastasis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Areti-Maria Vasilogianni  

LAB HEAD: Jill Barber

PROVIDER: PXD038776 | Pride | 2023-05-10

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis.

Vasilogianni Areti-Maria AM   Al-Majdoub Zubida M ZM   Achour Brahim B   Peters Sheila Annie SA   Rostami-Hodjegan Amin A   Barber Jill J  

Frontiers in oncology 20230220

<h4>Introduction</h4>Alterations in expression and activity of human receptor tyrosine kinases (RTKs) are associated with cancer progression and in response to therapeutic intervention.<h4>Methods</h4>Thus, protein abundance of 21 RTKs was assessed in 15 healthy and 18 cancerous liver samples [2 primary and 16 colorectal cancer liver metastasis (CRLM)] matched with non-tumorous (histologically normal) tissue, by a validated QconCAT-based targeted proteomic approach.<h4>Results</h4>It was demonst  ...[more]

Similar Datasets

Proteomics Quantitative LC-MS/MS Proteomics of paediatric human liver microsomes
2021-09-09 | PXD020844 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of microsomal fractions from adult human livers
2021-09-09 | PXD021025 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of paediatric human liver microsomes (set 2)
2021-09-09 | PXD020939 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human liver microsomes
2021-09-08 | PXD020910 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of paediatric biliary atresia human liver microsomes
2021-09-09 | PXD020974 | Pride
Proteomics An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer
2020-08-27 | PXD020913 | Pride
Proteomics Proteomic data for tumor pericytes derived from colorectal cancer patients
2024-01-26 | PXD033011 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human brain microvessels
2021-09-09 | PXD021018 | Pride
Proteomics Quantitative LC-MS/MS proteomics of human kidney microsomes
2021-08-30 | PXD020996 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human small intestine
2021-09-09 | PXD020987 | Pride