Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: Tomoichiro Miyoshi
LAB HEAD: Tomoichiro Miyoshi
PROVIDER: PXD038851 | Pride | 2023-03-11
REPOSITORIES: Pride
Luqman-Fatah Ahmad A Watanabe Yuzo Y Uno Kazuko K Ishikawa Fuyuki F Moran John V JV Miyoshi Tomoichiro T
Nature communications 20230113 1
Some interferon stimulated genes (ISGs) encode proteins that inhibit LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-encoded protein (ORF1p) in ribonucleoprotein particles. Three ISG proteins that interact with ORF1p inhibit retrotransposition: HECT and RLD domain containing E3 ubiquitin-protein ligase 5 (HERC5); 2'-5'-oligoadenylate synthetase-like (OASL); and helicas ...[more]