Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Escherichia Coli
SUBMITTER: Luisa Welp
LAB HEAD: Dr. Katharina Höfer
PROVIDER: PXD038910 | Pride | 2023-06-01
REPOSITORIES: Pride
Wolfram-Schauerte Maik M Pozhydaieva Nadiia N Grawenhoff Julia J Welp Luisa M LM Silbern Ivan I Wulf Alexander A Billau Franziska A FA Glatter Timo T Urlaub Henning H Jäschke Andres A Höfer Katharina K
Nature 20230816 7976
The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When bacteriophage T4 infects Escherichia coli, it uses three different adenosine diphosphate (ADP)-ribosyltransferases (ARTs) to reprogram the transcriptional and translational apparatus of the host by ADP-ribosylation using nicotinamide adenine dinucleotide (NAD) as a substrate<sup>1,2</sup>. NAD has previously been identified as a 5' modification of cellular RNAs<sup>3-5</sup>. Here ...[more]