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Human ZDHHC13 phosphorylation test

ABSTRACT: We use microcapillary LC/MS/MS to examine the phosphorylation sites of purified human ZDHHC13 protein.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Shuyang Chen

LAB HEAD: Shuyang Chen

PROVIDER: PXD038934 | Pride | 2023-10-24

REPOSITORIES: Pride

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AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis.

Sun Yu Y Li Xin X Yin Chengqian C Zhang Judy J Liang Ershang E Wu Xianfang X Ni Ying Y Arbesman Joshua J Goding Colin R CR Chen Shuyang S

Cancer research 20230401 7

Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated by the protein acyltransferase zinc finger DHHC-type palmitoyltransferase 13 (ZDHHC13). A better understanding of how ZDHHC13 is physiologically activated could help identify approaches to prevent melanomagenesis in redheads. He ...[more]

PMID: 36701140

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