Kinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127

ABSTRACT: Here we identify that drug-resistant BTK mutations occur in distinct enzymatic classes, some of which render BTK enzymatically impaired while conferring novel protein-protein interactions to sustain B-cell receptor (BCR) signaling.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell

DISEASE(S): Lymphoma

SUBMITTER: Skye Montoya  

LAB HEAD: Justin Taylor

PROVIDER: PXD039012 | Pride | 2023-12-09

REPOSITORIES: Pride