Proteomics

Dataset Information

0

Signaling network response to alpha-particle targeted therapy with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N


ABSTRACT: Alpha-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted alpha-particle therapy (TAT). Identification of the radiation-activated mechanisms, which drive cancer cell survival, provides opportunities to develop new points for therapeutic interference to improve the efficacy and safety of TAT. Quantitative phosphoproteomics and matching proteomics followed were employed to identify alterations in the signaling networks in response to TAT with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N in A431 cells, which overexpress cholecystokinin B receptor (CCKBR).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin Epidermis, Cell Culture

DISEASE(S): Cancer

SUBMITTER: Michal Grzmil  

LAB HEAD: Michal Grzmil

PROVIDER: PXD039033 | Pride | 2023-06-02

REPOSITORIES: Pride

Similar Datasets

2015-06-15 | E-GEOD-65687 | biostudies-arrayexpress
2012-12-07 | E-GEOD-42423 | biostudies-arrayexpress
2023-05-25 | PXD027856 | Pride
2011-11-06 | E-GEOD-30736 | biostudies-arrayexpress
2013-05-31 | E-GEOD-42191 | biostudies-arrayexpress
2014-12-15 | E-GEOD-37183 | biostudies-arrayexpress
2013-02-12 | E-GEOD-44265 | biostudies-arrayexpress
2022-08-11 | PXD012842 | Pride
2023-01-02 | PXD035587 | Pride
2021-11-02 | PXD019728 | Pride