Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Anja Stefanski
LAB HEAD: Kai Stühler
PROVIDER: PXD039063 | Pride | 2023-05-10
REPOSITORIES: Pride
Skowron Margaretha A MA Kotthoff Mara M Bremmer Felix F Ruhnke Katja K Parmaksiz Fatma F Richter Annika A Küffer Stefan S Reuter-Jessen Kirsten K Pauls Stella S Stefanski Anja A Ströbel Philipp P Stühler Kai K Nettersheim Daniel D
Molecular medicine (Cambridge, Mass.) 20230329 1
<h4>Background</h4>Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) component, resulting in poor prognosis due to lack of novel treatment options besides chemotherapy and surgery. The aim of this study was to identify novel targets for the treatment of YST by deciphering the molecular mechanisms of therapy resistance. Ad ...[more]