Proteomics

Dataset Information

Spint1 specific knokout in mouse pancreas islet SILAC

ABSTRACT: SPINT1 is a membrane-anchored serine protease inhibitor that modulates pericellular proteolysis. The pancreas-specific disruption of Spint1 in mice significantly decreased islet size and mass, leading to glucose intolerance, which was causally related to the down-regulation of MafA and insulin. Mechanistically, the silencing of Hepsin (encoding a SPINT1 target protease) counteracted the repressive effect of Spint1 knockdown on MafA and Ins1 expression in β cells. Together, the results suggest that SPINT1 plays a novel role in β cells to maintain glucose homeostasis and insulin production.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Lin hsin-hsien  

LAB HEAD: Ming-Shyue Lee

PROVIDER: PXD039190 | Pride | 2024-11-01

REPOSITORIES: Pride

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Action DRS
2016-1209_HPH-10__2017_01_02_15_44_26_UTC_.raw Raw
2016-1209_HPH-11__2017_01_02_15_44_26_UTC_.raw Raw
2016-1209_HPH-12__2017_01_02_15_44_26_UTC_.raw Raw
2016-1209_HPH-13__2017_01_02_15_44_26_UTC_.raw Raw
2016-1209_HPH-14__2017_01_02_15_44_26_UTC_.raw Raw
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