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Bacillus subtilis spo0A trade-off

ABSTRACT: This project is about the proteomes of wild type cells (WT) and spo0A-null strain of B. subtilis during exponential growth in mannose medium. B2 & B4 corresponds to the wild type cells (two biological replicate samples) and B6 & B8 corresponds to spo0A-null data (two biological replicate samples).

INSTRUMENT(S): timsTOF

ORGANISM(S): Bacillus Subtilis Subsp. Subtilis Str. 168

TISSUE(S): Bacteriocyte

SUBMITTER: Xiongfeng Dai

LAB HEAD: Xiongfeng Dai

PROVIDER: PXD039192 | Pride | 2023-05-10

REPOSITORIES: Pride

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A fitness trade-off between growth and survival governed by Spo0A-mediated proteome allocation constraints in Bacillus subtilis.

Zhu Manlu M Wang Qian Q Mu Haoyan H Han Fei F Wang Yanling Y Dai Xiongfeng X

Science advances 20230927 39

Growth and survival are key determinants of bacterial fitness. However, how resource allocation of bacteria could reconcile these two traits to maximize fitness remains poorly understood. Here, we find that the resource allocation strategy of Bacillus subtilis does not lead to growth maximization on various carbon sources. Survival-related pathways impose strong proteome constraints on B. subtilis. Knockout of a master regulator gene, spo0A, triggers a global resource reallo ...[more]

PMID: 37756393

Publication: 1/2

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