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Targeting Supramolecular Active Complexes of Nav 1.7/Nav 1.8 to Relieve Chronic Neuropathic Pain

ABSTRACT: The aim of this project was to identify the proteins participating in assemble of supramolecular active complex containing Nav1.7 and Nav1.8 in dorsal root ganglia (DRG) of mice with nerve injury 6 weeks. DRG and spinal dorsal horn (SDH) tissues were collected from spared nerve injury mice and sham-operated mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Neuron, Sensory Ganglion

DISEASE(S): Neuropathic Pain

SUBMITTER: Changgeng Peng

LAB HEAD: Changgeng Peng

PROVIDER: PXD039251 | Pride | 2026-07-29

REPOSITORIES: Pride

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			Action	DRS
	R20210801688_P1.raw	Raw
	R20210801688_P10.raw	Raw
	R20210801688_P11.raw	Raw
	R20210801688_P12.raw	Raw
	R20210801688_P13.raw	Raw

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Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain.

Sun Liting L Xian Hang H Shi Yunxin Y Yang Taotan T Shuai Hongyan H Hu Wenchao W Fei Siying S Xu Miao M Yang Taoyuan T Xia Ruilong R Wen Ting T Zhu Fengting F Fu Yan Y Li Yang Y Xia Wei W Qian Ran R Liu Yuanying Y Tian Zhicheng Z Li Lamei L Zhou Qian Q Xiong Lize L Cong Rui R Luo Ceng C Wu Shengxi S Shen Xiafeng X Yu Xin X Xie Rou-Gang RG Peng Changgeng C

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20260520 41

Neuropathic pain (NP) affects 7%-10% of population, with current treatments often proving inadequate. Here we show that Nav1.7 and Nav1.8 form supramolecular active complexes (SMACs) with polygonal lattice structure in dorsal root ganglion (DRG) neurons of mouse models and patients with severe chronic NP. TrkB signaling facilitates the formation of Nav1.7/Nav1.8 SMACs. Targeting these SMACs with combined Nav1.7 and Nav1.8 blockers ...[more]

PMID: 42159924

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