Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Prostate Gland
DISEASE(S): Prostate Cancer
SUBMITTER: Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD039272 | Pride | 2023-01-05
REPOSITORIES: Pride
Hsu En-Chi EC Rice Meghan A MA Bermudez Abel A Marques Fernando Jose Garcia FJG Aslan Merve M Liu Shiqin S Ghoochani Ali A Zhang Chiyuan Amy CA Chen Yun-Sheng YS Zlitni Aimen A Kumar Sahil S Nolley Rosalie R Habte Frezghi F Shen Michelle M Koul Kashyap K Peehl Donna M DM Zoubeidi Amina A Gambhir Sanjiv S SS Kunder Christian A CA Pitteri Sharon J SJ Brooks James D JD Stoyanova Tanya T
Proceedings of the National Academy of Sciences of the United States of America 20200113 4
Resistance to androgen deprivation therapy, or castration-resistant prostate cancer (CRPC), is often accompanied by metastasis and is currently the ultimate cause of prostate cancer-associated deaths in men. Recently, secondary hormonal therapies have led to an increase of neuroendocrine prostate cancer (NEPC), a highly aggressive variant of CRPC. Here, we identify that high levels of cell surface receptor Trop2 are predictive of recurrence of localized prostate cancer. Moreover, Trop2 is signif ...[more]