Proteomics

Dataset Information

0

Elevated PAF1-RAD52 Axis Confers Chemoresistance to Human Cancers


ABSTRACT: To identify a common protein that interacts with PAF1 in ovarian cancer, lung Cancer, and pancreatic cancer to mediate chemoresistance.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Lung Cancer,Pancreatic Cancer,Malignant Neoplasm Of Ovary

SUBMITTER: Moorthy Ponnusamy  

LAB HEAD: Moorthy P. Ponnusamy

PROVIDER: PXD039281 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications


Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human cancers (ovarian, lung, and pancreas). Mechanistically, cisplatin- and gemcitabine-resistant cells show enhanced DNA repair, which is inhibited by PAF1 silencing. We demonstrate an increased interaction  ...[more]

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