Elevated PAF1-RAD52 Axis Confers Chemoresistance to Human Cancers
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Lung Cancer,Pancreatic Cancer,Malignant Neoplasm Of Ovary
SUBMITTER: 
Moorthy Ponnusamy
LAB HEAD: Moorthy P. Ponnusamy
PROVIDER: PXD039281 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
Rauth Sanchita S Ganguly Koelina K Atri Pranita P Parte Seema S Nimmakayala Rama Krishna RK Varadharaj Venkatesh V Nallasamy Palanisamy P Vengoji Raghupathy R Ogunleye Ayoola O AO Lakshmanan Imayavaramban I Chirravuri Ramakanth R Bessho Mika M Cox Jesse L JL Foster Jason M JM Talmon Geoffrey A GA Bessho Tadayoshi T Ganti Apar Kishor AK Batra Surinder K SK Ponnusamy Moorthy P MP
Cell reports 20230128 2
Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human cancers (ovarian, lung, and pancreas). Mechanistically, cisplatin- and gemcitabine-resistant cells show enhanced DNA repair, which is inhibited by PAF1 silencing. We demonstrate an increased interaction ...[more]
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