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Tissue expression of N-terminal proteoforms.

ABSTRACT: To evaluate the expression of N-terminal proteoforms (protein isoforms with different N-terminus expressed from the same gene) in healthy human tissues, we re-analyzed public proteomics data of the draft map of the human proteome developed by the Pandey group (PRIDE project PXD000561). Using ionbot search engine and a custom-build protein sequence database (composed of UniProt and Ribo-seq derived proteoforms) we confirmed that N-terminal proteoforms are not only expressed in histologically healthy human tissues, but also display tissue specificity.

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Testis, Brain, Prostate Gland, Gastrointestinal Tract, Liver, Lung, Blood, Kidney, Ovary, Placenta, Nerve Cord, Colon, Urinary Bladder, Adrenal Gland

SUBMITTER: Daria Fijalkowska

LAB HEAD: Prof. Dr. Kris Gevaert

PROVIDER: PXD039339 | Pride | 2023-06-12

REPOSITORIES: Pride

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