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Non-labelled proteomics expression analysis of PC-3 cells treated with transferrin conjugated gold nanoparticles

ABSTRACT: Nanoparticles-based therapeutics are being clinically translated for treating cancer. Meanwhile nanoparticles are increasingly being identified as impacting cell regulation and protein expression. Here, we sought to understand how a model of a relatively inert nanoparticle without any therapeutic agent itself interact with the cells and what are the key biological mechanisms.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Sonia Theresa Sebastian

LAB HEAD: Associate Professor Ivan Kempson

PROVIDER: PXD039433 | Pride | 2023-10-24

REPOSITORIES: Pride

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Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway.

Sebastian Sonia S Hoffmann Manuela Klingler MK Howard Douglas D Young Clifford C Washington Jenni J Unterweger Harald H Alexiou Christoph C Turnbull Tyron T D'Andrea Richard R Hoffmann Peter P Kempson Ivan I

Antioxidants (Basel, Switzerland) 20230815 8

Nanoparticle-based therapeutics are being clinically translated for treating cancer. Even when thought to be biocompatible, nanoparticles are being increasingly identified as altering cell regulation and homeostasis. Antioxidant pathways are important for maintaining cell redox homeostasis and play important roles by maintaining ROS levels within tolerable ranges. Here, we sought to understand how a model of a relatively inert nanoparticle without any therapeutic agent itself could antagonize a ...[more]

PMID: 37627612

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SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

2014-07-11 | E-GEOD-59284 | biostudies-arrayexpress

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