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Y79 retinoblastoma cell line secretome

ABSTRACT: The proteins secreted from Y79 retinoblastoma cell line were analyzed by the GeLC-MS/MS approach.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Retinoblastoma

SUBMITTER: Yuzuru Shiio

LAB HEAD: Yuzuru Shiio

PROVIDER: PXD039515 | Pride | 2024-01-26

REPOSITORIES: Pride

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Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma.

Jayabal Panneerselvam P Zhou Fuchun F Ma Xiuye X Bondra Kathryn M KM Blackman Barron B Weintraub Susan T ST Chen Yidong Y Chévez-Barrios Patricia P Houghton Peter J PJ Gallie Brenda B Shiio Yuzuru Y

Cell reports 20230213 2

Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses nitric oxide and enables retinoblastoma growth. We show that coxsackievirus and adenovirus receptor (CXADR) is the cell-surface receptor for SFRP2 in retinoblastoma cells; that CXADR functions as a "dependence receptor," transmitting a growth-inhibitory sign ...[more]

PMID: 36773293

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