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Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots

ABSTRACT: The two major mammalian adipose tissue depots are subcutaneous adipose tissue (SAT), which is associated with metabolic protection, and abdominal/visceral (VAT), which contributes to metabolic disease. To investigate the molecular underpinnings of these differences, we conducted a comprehensive analysis of the proteomes of adipocytes and whole tissue from these different depots across two different diets in male C57Bl/6J mice.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epididymal White Adipose Tissue, White Adipocyte, Subcutaneous Adipose Tissue

SUBMITTER: Sean Humphrey

LAB HEAD: David James

PROVIDER: PXD039523 | Pride | 2023-02-13

REPOSITORIES: Pride

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