Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Skin
DISEASE(S): Melanoma
SUBMITTER: Martina Samiotaki
LAB HEAD: Efstratios Stratikos
PROVIDER: PXD039584 | Pride | 2023-11-21
REPOSITORIES: Pride
Temponeras Ioannis I Samiotaki Martina M Koumantou Despoina D Nikopaschou Martha M Kuiper Jonas J W JJW Panayotou George G Stratikos Efstratios E
European journal of immunology 20230515 8
ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues of peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory site that accommodates the C-terminus of at least some peptide substrates, raising questions about its exact influence on antigen presentation and the potential of allosteric inhibition for cancer immunotherapy. We used an inhibi ...[more]