Adaptive resistance to MEK and PI3K inhibition in pancreatic cancer cells

ABSTRACT: Pancreatic cancer is one of the most lethal cancers. Preclinical studies have shown adaptive resistance to Raf/MEK/ERK and PI3K/Akt pathway inhibition. We identify common protein expression alterations associated with adaptive resistance to MEK and PI3K kinase inhibition in KRas-mutant pancreatic cancer cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Ductal Adenocarcinoma Cell Line, Epithelium Of Pancreatic Duct

DISEASE(S): Pancreas Adenocarcinoma

SUBMITTER: Juan Francisco Martinez-Aguilar  

LAB HEAD: Juan F

PROVIDER: PXD039692 | Pride | 2025-03-10

REPOSITORIES: Pride