C9orf72 ubiquitin and interaction proteomics

ABSTRACT: C9orf72 binds SMCR8 to from a robust complex that regulates small GTPases, lysosomal integrity and autophagy. In contrast to this functional understanding, we know far less about assembly and turnover of the C9orf72-SMCR8 complex. Loss of either subunit causes the concurrent ablation of the respective partner. However, the molecular mechanism underlying this interdependence remains elusive.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Parkinson's Disease

SUBMITTER: Christian Behrends  

LAB HEAD: Christian Behrends

PROVIDER: PXD039887 | Pride | 2023-05-10

REPOSITORIES: Pride