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Structure and antigenicity of divergent Henipavirus fusion glycoproteins

ABSTRACT: A novel henipavirus (HNV) named Langya virus (LayV) was isolated in human patients in China in August 2022. It is closely related to Mòjiāng virus (MojV) and represents the first instance of HNV zoonosis to humans outside of Nipah virus (NiV) and Hendra viruses (HeV). Within this work, mass spectrometry glycoproteomic analysis revealed that although the LayV F protein has reduced glycosylation compared to its NiV and HeV counterparts, a unique glycan was identified positioned at the DIII apex, shielding a previously identified site of vulnerability in NiV F.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)

SUBMITTER: Kyle Macauslane

LAB HEAD: Benjamin L. Schulz

PROVIDER: PXD039898 | Pride | 2023-05-03

REPOSITORIES: Pride

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