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The direct effect of mycophenolate mofetil on podocytes in nephrotoxic serum nephritis

ABSTRACT: The goal of our study was to characterize glomerulus and particularly podocyte biology during MMF treatment in an immune-triggered proteinuric glomerulopathy. Therefore, nephrotoxic serum nephritis was induced in three-week old wild-type mice. On day 3, half of the mice were treated with MMF (100 mg/kgBW/d p.o.) (NTS+MMF) for one week, the other half of animals with vehicle (NTS+veh). A further group without induction and treatment served as controls (C). On day 10, we performed proteomic analysis of glomeruli.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Glomerular Cell, Kidney

SUBMITTER: Prerana Wagle

LAB HEAD: Agnes Hackl

PROVIDER: PXD039915 | Pride | 2023-08-30

REPOSITORIES: Pride

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