Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
SUBMITTER: Randeep Rakwal
LAB HEAD: Randeep Rakwal
PROVIDER: PXD039992 | Pride | 2023-03-11
REPOSITORIES: Pride
Shibato Junko J Takenoya Fumiko F Yamashita Michio M Gupta Ravi R Min Cheol Woo CW Kim Sun Tae ST Kimura Ai A Takasaki Ichiro I Hori Motohide M Shioda Seiji S Rakwal Randeep R
International journal of molecular sciences 20230220 4
The study aimed to understand mechanism/s of neuronal outgrowth in the rat adrenal-derived pheochromocytoma cell line (PC12) under pituitary adenylate cyclase-activating polypeptide (PACAP) treatment. Neurite projection elongation was suggested to be mediated via Pac1 receptor-mediated dephosphorylation of CRMP2, where GSK-3β, CDK5, and Rho/ROCK dephosphorylated CRMP2 within 3 h after addition of PACAP, but the dephosphorylation of CRMP2 by PACAP remained unclear. Thus, we attempted to identify ...[more]